Benzo a pyrene biotransformation pdf

In this study, the microinteraction of contaminants on the cellular surface was investigated. Find, read and cite all the research you need on researchgate. Systems toxicology approach to understand the kinetics of benzo apyrene uptake, biotransformation, and dna adduct formation in a liver cell model. Bioavailability and biotransformation of benzo apyrene in an isolated perfused in situ catfish intestinal preparation. Modification of benzoapyrene metabolism in hepatic microsomes from. The uptake, metabolism, and biological halflife of benzoapyrene. Benzoapyrene exposure through dietary fat altered its metabolic fate in a dosedependent manner, with 100 ugkg dose group registering an elevated expression of bap biotransformation enzymes, and greater concentration of bap metabolites, compared to the 50 ugkg dose group p benzo apyrene is a fivering polycyclic aromatic hydrocarbon pah. Detoxication of benzoapyrene7,8dione by sulfotransferases. Previous studies have confirmed that stenotrophomonas maltophilia can bind an appreciable amount of cuii and degrade bap. Pdf metabolism of benzoapyrene and benzoapyrene7,8diol. However, the removal mechanisms of cuii coexisted with bap by s.

Bioavailability and biotransformation of benzoapyrene in an. Pdf benzo a pyrene at human blood equivalent level. The enzyme activities of the fungus lasiodiplodia theobromae l. Benzo a pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling.

Kinetics and biotransformation of benzo a pyrene inchironomus. Pdf biotransformation, hepatopancreas dna binding and. Metabolism of benzoapyrene and benzoapyrene7,8diol by human cytochrome p450 1b1. The kinetics of uptake and metabolism of benzoapyrene bap were studied in various tissues of a marine fish, the sea bass dicentrarchus labrax, alter.

In addition, we determined the thermal sensitivity 39 of the xenobiotic biotransformation enzymes. Get a printable copy pdf file of the complete article 4. This article has been cited by other articles in pmc. Pdf bioavailability and biotransformation of benzoa. Polycyclic aromatic hydrocarbons, of which benzoapyrene bap.

Metabolic activation of benzoapyrene in vitro by hepatic. Benzo apyrene along with other pahs is released into the atmosphere as a component of smoke from forest fires, industrial processes, vehicle exhaust, cigarettes, and through the burning of fuel such as wood, coal, and petroleum products. Biotransformation of benzoapyrene and other polycyclic aromatic. Pdf benzo alpha pyrene bap is a prototype polycyclic aromatic hydrocarbon pah. Quantitative analysis of benzoapyrene biotransformation and adduct formation. Permanent fish cell lines constitute a promising complement or substitute for fish in the environmental risk assessment of chemicals.

Biotransformation of benzo a pyrene analysis, metabolism and adduct formation in rats and ahr knockout mice dissertation for the degree of ph. Seasonal biotransformation of naphthalene, phenanthrene, and benzo a pyrene in surficial estuarine sediments. Polycyclic aromatic hydrocarbons benzoapyrene toxicological. Bioavailability and biotransformation of benzoapyrene in. Biotransformation of benzoapyrene analysis, metabolism. Bioavailability and biotransformation of benzoapyrene in an isolated perfused in situ catfish intestinal preparation. Biotransformation of benzoapyrene by three rainbow trout. This laboratory has shown that the metabolism of benzoapyrene bap, a carcinogenic polycyclic aromatic hydrocarbon pah, by a. We demonstrate the potential of a set of cell lines originating from rainbow trout oncorhynchus mykiss to aid in the prediction of chemical bioaccumulation in fish, using benzo apyrene bap as a model chemical. Biotransformation, hepatopancreas dna binding and pharmacokinetics of benzo apyrene after oral and parenteral administration to the american lobster, homarus americanus. Enzyme activities during benzoapyrene degradation by the. Uptake and depuration kinetics for benzoapyrene bap were determined for the midgechironomus riparius diptera with one and two compartment models. Biotransformation of benzo apyrene by the thermophilic bacterium bacillus licheniformis m27 article pdf available in world journal of microbiology and biotechnology 347.