Mollarets meningitis fulltext european neurology 2008, vol. When initially described, this form of aseptic meningitis had no identifiable infecting agent. Recurrent benign lymphocytic meningitis clinical infectious. It was named for pierre mollaret, the french neurologist who first described it. The disease is most often caused by herpes simplex virus type 2 hsv2 and less frequently by other viruses, autoimmune disorders, or medication. The recurrent meningitis association was started because there was a need to advocate for those with recurrent viral meningitis. Meningitis recurrente enfermedades cerebrales, medulares. It has been suggested that if the strict criteria above are followed, these cases should be excluded, and the term mollaret s meningitis reserved for true idiopathic cases. In general, meningitis caused by a virus is less serious than meningitis caused by bacteria. Cases of idiopathic recurrent benign aseptic meningitis were first described by.
The peripheral white blood cell count alone is not help. Descrita por primera vez en 1944 por pierre mollaret como una meningitis endoteliolinfocitica recurrente caracterizada por presentarse en pacientes por lo demas sanos. Pdf mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Meningitis recurrente enfermedades cerebrales, medulares y. Herpes simplex type 2 virus is the causative agent in virtually all cases.
When initially described by mollaret, this form of aseptic meningitis had no identifiable infecting agent. It is not known why one person gets meningitis when others exposed to the same germs do not get as sick, or dont get sick at all. Recurrent aseptic meningitis secondary to intracranial epidermoids. Benign recurrent aseptic meningitis is a rare disorder described by mollaret in 1944. Mollarets meningitisrecurrent aseptic meningitishsv2 virus. Nov 01, 2006 recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. Jan 25, 2019 mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times.
Elsevier case reports mollaret s recurrent aseptic meningitis and cerebral epidermoid cyst fernandez j. Mollarets meningitis benign recurrent aseptic meningitis. Nowadays, the genomic era allows a strict specific etiological diagnosis. Hermosa, md a patient who initially presented with clinical and laboratory signs of bacterial meningitis developed four more similar episodes within a 6month period. Mollaret meningitis genetic and rare diseases information. For language access assistance, contact the ncats public information officer.
Herpes simplex virus type 2 recurrent meningitis mollarets. Common signs and symptoms during an episode may include severe headache, fever, nausea, vomiting, sensitivity to light photophobia, and stiff neck. Recurrent herpes simplex type 2 virus mollaret meningitis. Kinohshita t, matsushima a, satoh s, et al 2014 a case of colchicineresponsive mollaret s meningitis with mefv gene mutation. Sometimes funguses, cancers, head injuries or other factors can cause meningitis, but cases from these sources are rare. Presented here is a new case of benign recurrent aseptic meningitis, or mollaret s meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain. Like other meningitis caused by different etiologies, this is generally known in the international literature as mollaret s syndrome.
Herpes simplex virus type 2associated recurrent aseptic. Pdf mollaret s meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Diagnosis, initial management, and prevention of meningitis. Mollaret meningitis is a rare form of meningitis that is recurrent, aseptic, mild, and selflimiting. Our founder, michael hrehor, was told he had recurrent viral meningitis when he was originally diagnosed in 2009. Mollarets meningitis and herpes simplex virus type 1 nejm. Sato r1, ayabe m, shoji h, ichiyama t, saito y, hondo r, eizuru y. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Mollarets meningitis and herpes simplex virus type 2.
Canadian journal of neurological sciences journal canadien des sciences neurologiques, vol. A patient who initially presented with clinical and laboratory signs of bacterial meningitis developed four more similar episodes within a 6month period. He went online to look for information and wasnt really able to find anything. It is characterized by repeated episodes of meningitis, typically lasting two to five days, occurring weeks to years apart.
Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and meningeal irritation with no obvious etiology. By continuing to use our website, you are agreeing to our use of cookies. Mollarets recurrent aseptic meningitis and cerebral. A tentative diagnosis of mollaret s meningitis was established after the third episode. Since mollaret s meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. Our patient is a paradigmatic model of recurrent meningitis properly diagnosed as herpes simplex type2 recurrent meningitis. In many ways it resembles recurrent hereditary polyserositis familial mediterranean fever in its natural history, pattern of attacks, and response to colchicine. If you have problems viewing pdf files, download the latest version of adobe reader. Mollaret meningitis is a rare form of meningitis that is recurrent. Mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Read mollaret s recurrent aseptic meningitis and cerebral epidermoid cyst, pediatric neurology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Mollaret s meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Cranial computed tomography performed during the acute phase of the initial episode was normal, but, after the. Recurrent lymphocytic meningitis positive for herpes simplex.
Recurrent herpes simplex type 2 virus mollaret meningitis jabfm. Mollarets meningitis is a rare condition with a characteristic clinical and cerebrospinal fluid picture. In recent years there has been increasing evidence to implicate the herpes simplex virus 2 hsv2 in many cases. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. Recurrent lymphocytic meningitis rlm is a rare disease, characterized by attacks of sudden onset aseptic meningitis followed by complete recovery and unpredictable recurrences. Ver informacion relacionada con meningitis recurrente benigna mollaret. This syndrome is associated with tra we use cookies to enhance your experience on our website. Herpes simplex virus type 2associated recurrent aseptic mollaret s meningitis in genitourinary medicine clinic.
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